If the required skill is not high enough, the Beast will take over and kill her.

Not preventing this results in a Masquerade Violation and Samantha will continuously follow the fledgling until dealt with. She says she will contact their friends and family. After completing the quest Dead Ex, she will confront the fledgling in Hollywood, beside herself with shock and relief. Samantha has been searching for the fledgling for an indeterminate amount of time, starting prior to the game's events.